The research goals of my laboratory are to parse the roles of genetic variation and environmental exposures in the development of asthma and allergic diseases using genetic, transcriptomic and epigenomic markers and integrated omic and systems level analyses. We focus our studies on freshly isolated (ex vivo) blood and airway cells and in vitro cell culture models of gene-environment interactions. Our studies are in diverse U.S. populations of children and adults who have been followed longitudinally and have detailed phenotypes and environmental assessments.
Northwestern University
Evanston, IL
PhD - Biological AnthropologyGeorge Washington University
Washington, D.C.
BA - AnthropologyMulti-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations.
Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations. Nat Commun. 2024 May 28; 15(1):4546.
PMID: 38806494EndoPRS: Incorporating Endophenotype Information to Improve Polygenic Risk Scores for Clinical Endpoints.
EndoPRS: Incorporating Endophenotype Information to Improve Polygenic Risk Scores for Clinical Endpoints. medRxiv. 2024 May 24.
PMID: 38826253Population descriptors in asthma and allergy research: Time to regroup.
Population descriptors in asthma and allergy research: Time to regroup. J Allergy Clin Immunol. 2024 Jul; 154(1):79-81.
PMID: 38642714Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop.
Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop. J Allergy Clin Immunol. 2024 Apr; 153(4):954-968.
PMID: 38295882Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma. J Allergy Clin Immunol. 2024 Mar; 153(3):809-820.
PMID: 37944567Revealing polygenic pleiotropy using genetic risk scores for asthma.
Revealing polygenic pleiotropy using genetic risk scores for asthma. HGG Adv. 2023 10 12; 4(4):100233.
PMID: 37663543Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.
Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis. Allergy. 2023 10; 78(10):2698-2711.
PMID: 37571876Asthma-protective agents in dust from traditional farm environments.
Asthma-protective agents in dust from traditional farm environments. J Allergy Clin Immunol. 2023 09; 152(3):610-621.
PMID: 37271318Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1+?non-immune cells in human spontaneous preterm labor.
Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1+?non-immune cells in human spontaneous preterm labor. Sci Rep. 2023 05 16; 13(1):7903.
PMID: 37193763A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
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A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome. J Allergy Clin Immunol. 2023 06; 151(6):1609-1621.
PMID: 36754293Distinguished Service Professor
University of Chicago
2018Jonas Salk Health Leadership Award for Research
March of Dimes
2017Top 10 Clinical Research Achievement Award
Clinical Research Forum
2017John E. Salvaggio Memorial Lectureship
American Association of Asthma, Allergy and Clinical Immunology
2015Reuben M. Cherniak Lecturer
Petty Aspen Lung Conference
2015Fellow
American Association for the Advancement of Science (AAAS)
2014Named Blum-Riese Professor
University of Chicago
2010Northwestern Obstetrics and Gynecology Award
Northwestern University Medical School
2005Charles Reed Lectureship
American Association of Asthma, Allergy, and Immunology (AAAAI)
2005J. Christian Herr Award for Excellence in Basic or Applied Research in Reproductive Immunology
American Society of Reproductive Immunology (ASRI)
1996