The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
Northwestern University
Evanston, IL
PhD - Biological Anthropology
George Washington University
Washington, D.C.
BA - Anthropology
A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome. J Allergy Clin Immunol. 2023 Feb 06.
PMID: 36754293
Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.
Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings. PLoS Genet. 2023 01; 19(1):e1010594.
PMID: 36638096
Discerning asthma endotypes through comorbidity mapping.
Discerning asthma endotypes through comorbidity mapping. Nat Commun. 2022 11 07; 13(1):6712.
PMID: 36344522
New Insights Relating Gasdermin B to the Onset of Childhood Asthma.
New Insights Relating Gasdermin B to the Onset of Childhood Asthma. Am J Respir Cell Mol Biol. 2022 Oct; 67(4):430-437.
PMID: 35580164
African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans. Genome Med. 2022 09 29; 14(1):112.
PMID: 36175932
Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement. 2022 Jun 30.
PMID: 35770850
DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma. Proc Natl Acad Sci U S A. 2022 06 14; 119(24):e2116467119.
PMID: 35666868
Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region. Genome Med. 2022 05 24; 14(1):55.
PMID: 35606880
Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.
Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB. J Allergy Clin Immunol. 2022 09; 150(3):622-630.
PMID: 35381269
Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region.
Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. Nat Commun. 2021 10 21; 12(1):6115.
PMID: 34675193
Distinguished Service Professor
University of Chicago
2018
Jonas Salk Health Leadership Award for Research
March of Dimes
2017
Top 10 Clinical Research Achievement Award
Clinical Research Forum
2017
John E. Salvaggio Memorial Lectureship
American Association of Asthma, Allergy and Clinical Immunology
2015
Reuben M. Cherniak Lecturer
Petty Aspen Lung Conference
2015
Fellow
American Association for the Advancement of Science (AAAS)
2014
Named Blum-Riese Professor
University of Chicago
2010
Northwestern Obstetrics and Gynecology Award
Northwestern University Medical School
2005
Charles Reed Lectureship
American Association of Asthma, Allergy, and Immunology (AAAAI)
2005
J. Christian Herr Award for Excellence in Basic or Applied Research in Reproductive Immunology
American Society of Reproductive Immunology (ASRI)
1996