Yang Li, Ph.D.

Assistant Professor

Office Address: CLSC 325D
Telephone number: 773 834 4973

Research in the Li lab lies at interface of genetics, gene regulation,
and disease. A large part of our work aims to dissect the role of
genetic variation on gene regulation at multiple levels. In
particular, we develop computational approaches to study genetic
effects on gene regulatory mechanisms that have so far been
under-appreciated. These include RNA splicing, co-transcriptional
dynamics, and post-transcriptional processes. We study how dysregulation
of these processes play roles in complex disease. A second focus of
the lab is the use of state-of-the-art genomics tools such as
single-cell RNA-sequencing to understand cellular composition
and function in disease progression.