My research lies at the intersection of genomics, neuroscience, and bioinformatics. Our lab delves into the complexities of epigenomic regulation in the brain, influenced by both inherent genetic factors and life experiences. Developing and utilizing innovative single-cell multi-omics and spatial genomics methodologies, along with neural circuit analysis and integrative computational approaches, we interrogate dynamic epigenomic and gene regulation at the levels of individual cell types, brain regions, and neural circuits. Additionally, we aim to elucidate how life experiences interplay with individuals' genetics to leave enduring imprints on epigenetic regulation, thereby affecting behavior and the propensity for brain disorders.
The Salk Institute for Biological Studies
La Jolla
Postdoctoral Fellow - Epigenomics and Neuroscience
2022
The University of North Carolina at Chapel Hill
Chapel Hill
PhD - Bioinformatics and Computational Biology
2014
The University of North Carolina at Chapel Hill
Chapel Hill
MS - Statistics
2014
Purdue University
West Lafayette
MS - Developmental Biology
2008
Brain-wide correspondence of neuronal epigenomics and distant projections.
Brain-wide correspondence of neuronal epigenomics and distant projections. Nature. 2023 Dec; 624(7991):355-365.
PMID: 38092919
Bearing surface defect detection based on improved convolutional neural network.
Bearing surface defect detection based on improved convolutional neural network. Math Biosci Eng. 2023 May 22; 20(7):12341-12359.
PMID: 37501445
Single nucleus multi-omics identifies human cortical cell regulatory genome diversity.
Single nucleus multi-omics identifies human cortical cell regulatory genome diversity. Cell Genom. 2022 Mar 09; 2(3).
PMID: 35419551
DNA methylation atlas of the mouse brain at single-cell resolution.
DNA methylation atlas of the mouse brain at single-cell resolution. Nature. 2021 10; 598(7879):120-128.
PMID: 34616061
Epigenomic diversity of cortical projection neurons in the mouse brain.
Epigenomic diversity of cortical projection neurons in the mouse brain. Nature. 2021 10; 598(7879):167-173.
PMID: 34616065
Extraction of Distinct Neuronal Cell Types from within a Genetically Continuous Population.
Extraction of Distinct Neuronal Cell Types from within a Genetically Continuous Population. Neuron. 2020 07 22; 107(2):274-282.e6.
PMID: 32396852
Epigenetic silencing of a multifunctional plant stress regulator.
Epigenetic silencing of a multifunctional plant stress regulator. Elife. 2019 08 16; 8.
PMID: 31418686
CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping.
CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Nat Methods. 2017 08; 14(8):819-825.
PMID: 28650476
Functional Human Oocytes Generated by Transfer of Polar Body Genomes.
Functional Human Oocytes Generated by Transfer of Polar Body Genomes. Cell Stem Cell. 2017 01 05; 20(1):112-119.
PMID: 27840020
Molecular Criteria for Defining the Naive Human Pluripotent State.
Molecular Criteria for Defining the Naive Human Pluripotent State. Cell Stem Cell. 2016 10 06; 19(4):502-515.
PMID: 27424783