Yoav Gilad, PhD

The Gilad lab focuses on studying genetic and regulatory differences between humans and our close evolutionary relatives. Our long term goal is to identify the genetic basis of human-specific traits, including genetic variation that underlies higher susceptibility to certain diseases and disorders in humans than in other primates.

Weizmann Institute of Science
Rehovot, Israel
Ph.D. - Molecular Genetics
2003

Weizamnn Institute of Science
Rehovot, Israel
M.Sc. - Molecular Genetics
2000

Ben Gurion University
Beer-Sheva, Israel
B.Sc. - Molecular Genetics and Biochemistry
1998

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions.
Findley AS, Monziani A, Richards AL, Rhodes K, Ward MC, Kalita CA, Alazizi A, Pazokitoroudi A, Sankararaman S, Wen X, Lanfear DE, Pique-Regi R, Gilad Y, Luca F. Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. Elife. 2021 05 14; 10.
PMID: 33988505

Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees.
Mittleman BE, Pott S, Warland S, Barr K, Cuevas C, Gilad Y. Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees. Elife. 2021 Feb 17; 10.
PMID: 33595436

Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes.
Ward MC, Banovich NE, Sarkar A, Stephens M, Gilad Y. Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes. Elife. 2021 Feb 08; 10.
PMID: 33554857

A TAD Skeptic: Is 3D Genome Topology Conserved?
Eres IE, Gilad Y. A TAD Skeptic: Is 3D Genome Topology Conserved? Trends Genet. 2021 03; 37(3):216-223.
PMID: 33203573

Gene expression variability in human and chimpanzee populations share common determinants.
Fair BJ, Blake LE, Sarkar A, Pavlovic BJ, Cuevas C, Gilad Y. Gene expression variability in human and chimpanzee populations share common determinants. Elife. 2020 10 21; 9.
PMID: 33084571

Where Are the Disease-Associated eQTLs?
Umans BD, Battle A, Gilad Y. Where Are the Disease-Associated eQTLs? Trends Genet. 2021 02; 37(2):109-124.
PMID: 32912663

Effective study design for comparative functional genomics.
Kelley JL, Gilad Y. Effective study design for comparative functional genomics. Nat Rev Genet. 2020 07; 21(7):385-386.
PMID: 32332928

Alternative polyadenylation mediates genetic regulation of gene expression.
Mittleman BE, Pott S, Warland S, Zeng T, Mu Z, Kaur M, Gilad Y, Li Y. Alternative polyadenylation mediates genetic regulation of gene expression. Elife. 2020 06 25; 9.
PMID: 32584258

Prime time for primate functional genomics.
Housman G, Gilad Y. Prime time for primate functional genomics. Curr Opin Genet Dev. 2020 06; 62:1-7.
PMID: 32544775

Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis.
Hsiao CJ, Tung P, Blischak JD, Burnett JE, Barr KA, Dey KK, Stephens M, Gilad Y. Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis. Genome Res. 2020 04; 30(4):611-621.
PMID: 32312741

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