Yoav Gilad, PhD

The Gilad lab focuses on studying genetic and regulatory differences between humans and our close evolutionary relatives. Our long term goal is to identify the genetic basis of human-specific traits, including genetic variation that underlies higher susceptibility to certain diseases and disorders in humans than in other primates.

Weizmann Institute of Science
Rehovot, Israel
Ph.D. - Molecular Genetics
2003

Weizamnn Institute of Science
Rehovot, Israel
M.Sc. - Molecular Genetics
2000

Ben Gurion University
Beer-Sheva, Israel
B.Sc. - Molecular Genetics and Biochemistry
1998

Effective study design for comparative functional genomics.
Kelley JL, Gilad Y. Effective study design for comparative functional genomics. Nat Rev Genet. 2020 Jul; 21(7):385-386.
PMID: 32332928

Alternative polyadenylation mediates genetic regulation of gene expression.
Mittleman BE, Pott S, Warland S, Zeng T, Mu Z, Kaur M, Gilad Y, Li Y. Alternative polyadenylation mediates genetic regulation of gene expression. Elife. 2020 Jun 25; 9.
PMID: 32584258

Prime time for primate functional genomics.
Housman G, Gilad Y. Prime time for primate functional genomics. Curr Opin Genet Dev. 2020 Jun 13; 62:1-7.
PMID: 32544775

Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis.
Hsiao CJ, Tung P, Blischak JD, Burnett JE, Barr KA, Dey KK, Stephens M, Gilad Y. Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis. Genome Res. 2020 Apr; 30(4):611-621.
PMID: 32312741

Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation.
Selewa A, Dohn R, Eckart H, Lozano S, Xie B, Gauchat E, Elorbany R, Rhodes K, Burnett J, Gilad Y, Pott S, Basu A. Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation. Sci Rep. 2020 Jan 30; 10(1):1535.
PMID: 32001747

A comparison of gene expression and DNA methylation patterns across tissues and species.
Blake LE, Roux J, Hernando-Herraez I, Banovich NE, Perez RG, Hsiao CJ, Eres I, Cuevas C, Marques-Bonet T, Gilad Y. A comparison of gene expression and DNA methylation patterns across tissues and species. Genome Res. 2020 02; 30(2):250-262.
PMID: 31953346

Reorganization of 3D genome structure may contribute to gene regulatory evolution in primates.
Eres IE, Luo K, Hsiao CJ, Blake LE, Gilad Y. Reorganization of 3D genome structure may contribute to gene regulatory evolution in primates. PLoS Genet. 2019 07; 15(7):e1008278.
PMID: 31323043

Dynamic genetic regulation of gene expression during cellular differentiation.
Strober BJ, Elorbany R, Rhodes K, Krishnan N, Tayeb K, Battle A, Gilad Y. Dynamic genetic regulation of gene expression during cellular differentiation. Science. 2019 06 28; 364(6447):1287-1290.
PMID: 31249060

Discovery and characterization of variance QTLs in human induced pluripotent stem cells.
Sarkar AK, Tung PY, Blischak JD, Burnett JE, Li YI, Stephens M, Gilad Y. Discovery and characterization of variance QTLs in human induced pluripotent stem cells. PLoS Genet. 2019 04; 15(4):e1008045.
PMID: 31002671

A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees.
Ward MC, Gilad Y. A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees. Elife. 2019 04 08; 8.
PMID: 30958265

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