T. Conrad Gilliam, PhD

Marjorie I. and Bernard A. Mitchell Distinguished Service Professor of Human Genetics

Dean for Basic Science, Biological Sciences Division



My research focuses on the identification and characterization of heritable mutations that affect the nervous system. Research projects vary from genetic mapping of rare (Mendelian) disease mutations and characterization of their downstream consequences to the study of common heritable disorders using mouse models as well as genomic and bioinformatic approaches. I am collaborating with experts in data-mining and network topology, systems biology, large-scale computing, and statistical genetics to develop new approaches to map the multi-gene determinants of common neuropsychiatric disorders. By reducing possible gene-gene combinations to those documented in the literature or whole genome databases, we avoid the penalties of multiple-testing. We are also collaborating to build software solutions for large-scale data mining and data integration.

Harvard Medical School
Boston
Post-doc Fellow - Molecular Genetics
1985

University of London
Paddington, London
Post-doc Fellow - Molecular Genetics
1983

University of Missouri
Columbia, MO
PhD - Biochemistry
1981

Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources.
Sulakhe D, D'Souza M, Wang S, Balasubramanian S, Athri P, Xie B, Canzar S, Agam G, Gilliam TC, Maltsev N. Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources. Brief Bioinform. 2019 09 27; 20(5):1754-1768.
PMID: 29931155

Molecular Interaction Network Approach (MINA) identifies association of novel candidate disease genes.
Kara S, Hanna A, Pirela-Morillo GA, Gilliam CT, Wilson GD. Molecular Interaction Network Approach (MINA) identifies association of novel candidate disease genes. MethodsX. 2019; 6:1286-1291.
PMID: 31198690

Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources.
Sulakhe D, D'Souza M, Wang S, Balasubramanian S, Athri P, Xie B, Canzar S, Agam G, Gilliam TC, Maltsev N. Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources. Brief Bioinform. 2018 Jun 21.
PMID: 29931155

Chemokine expression in the early response to injury in human airway epithelial cells.
Xie B, Laxman B, Hashemifar S, Stern R, Gilliam TC, Maltsev N, White SR. Chemokine expression in the early response to injury in human airway epithelial cells. PLoS One. 2018; 13(3):e0193334.
PMID: 29534074

A p53-regulated apoptotic gene signature predicts treatment response and outcome in pediatric acute lymphoblastic leukemia.
Bainer RO, Trendowski MR, Cheng C, Pei D, Yang W, Paugh SW, Goss KH, Skol AD, Pavlidis P, Pui CH, Gilliam TC, Evans WE, Onel K. A p53-regulated apoptotic gene signature predicts treatment response and outcome in pediatric acute lymphoblastic leukemia. Cancer Manag Res. 2017; 9:397-410.
PMID: 28979163

Lynx: a knowledge base and an analytical workbench for integrative medicine.
Sulakhe D, Xie B, Taylor A, D'Souza M, Balasubramanian S, Hashemifar S, White S, Dave UJ, Agam G, Xu J, Wang S, Gilliam TC, Maltsev N. Lynx: a knowledge base and an analytical workbench for integrative medicine. Nucleic Acids Res. 2016 Jan 04; 44(D1):D882-7.
PMID: 26590263

Disease gene prioritization using network and feature.
Xie B, Agam G, Balasubramanian S, Xu J, Gilliam TC, Maltsev N, Börnigen D. Disease gene prioritization using network and feature. J Comput Biol. 2015 Apr; 22(4):313-23.
PMID: 25844670

An integrative computational approach for prioritization of genomic variants.
Dubchak I, Balasubramanian S, Wang S, Cem M, Meyden C, Sulakhe D, Poliakov A, Börnigen D, Xie B, Taylor A, Ma J, Paciorkowski AR, Mirzaa GM, Dave P, Agam G, Xu J, Al-Gazali L, Mason CE, Ross ME, Maltsev N, Gilliam TC. An integrative computational approach for prioritization of genomic variants. PLoS One. 2014; 9(12):e114903.
PMID: 25506935

Lynx web services for annotations and systems analysis of multi-gene disorders.
Sulakhe D, Taylor A, Balasubramanian S, Feng B, Xie B, Börnigen D, Dave UJ, Foster IT, Gilliam TC, Maltsev N. Lynx web services for annotations and systems analysis of multi-gene disorders. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W473-7.
PMID: 24948611

High-throughput translational medicine: challenges and solutions.
Sulakhe D, Balasubramanian S, Xie B, Berrocal E, Feng B, Taylor A, Chitturi B, Dave U, Agam G, Xu J, Börnigen D, Dubchak I, Gilliam TC, Maltsev N. High-throughput translational medicine: challenges and solutions. Adv Exp Med Biol. 2014; 799:39-67.
PMID: 24292961

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