Maanasa Raghavan, PhD

My group's research interests span questions and applications in multiple fields, including population genetics/genomics, anthropology, archaeology, and medical genetics. The big question driving our research is: ‘How have demographic, cultural, and environmental factors contributed over time to shaping the genetic profiles of present-day human populations?’ In order to address specific research questions embedded within this overarching goal, we use a combined approach that brings together genome-scale data from present-day and ancient humans and their biotic environment, especially domesticates and pathogens. Through the implementation of multiple complementary projects set within the context of South Asian and indigenous American populations, our research will ultimately contribute towards the understanding of the evolutionary mechanisms that underlie adaptations and diseases among human populations.

University of Copenhagen
Denmark
PhD - Paleogenomics (ancient DNA)
2011

University of Oxford
UK
MSc - Archaeological Sciences
2007

University of Toronto
Canada
BSc (Hons) - Molecular Biology
2006

An Ancient Genome from the Indus Valley Civilization.
Raghavan M, Schroeder H, Malaspinas AS. An Ancient Genome from the Indus Valley Civilization. Cell. 2019 Oct 17; 179(3):586-588.
PMID: 31626767

DNA evidence of bowhead whale exploitation by Greenlandic Paleo-Inuit 4,000 years ago.
Seersholm FV, Pedersen MW, Søe MJ, Shokry H, Mak SS, Ruter A, Raghavan M, Fitzhugh W, Kjær KH, Willerslev E, Meldgaard M, Kapel CM, Hansen AJ. DNA evidence of bowhead whale exploitation by Greenlandic Paleo-Inuit 4,000 years ago. Nat Commun. 2016 11 08; 7:13389.
PMID: 27824339

POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans.
Raghavan M, Steinrücken M, Harris K, Schiffels S, Rasmussen S, DeGiorgio M, Albrechtsen A, Valdiosera C, Ávila-Arcos MC, Malaspinas AS, Eriksson A, Moltke I, Metspalu M, Homburger JR, Wall J, Cornejo OE, Moreno-Mayar JV, Korneliussen TS, Pierre T, Rasmussen M, Campos PF, de Barros Damgaard P, Allentoft ME, Lindo J, Metspalu E, Rodríguez-Varela R, Mansilla J, Henrickson C, Seguin-Orlando A, Malmström H, Stafford T, Shringarpure SS, Moreno-Estrada A, Karmin M, Tambets K, Bergström A, Xue Y, Warmuth V, Friend AD, Singarayer J, Valdes P, Balloux F, Leboreiro I, Vera JL, Rangel-Villalobos H, Pettener D, Luiselli D, Davis LG, Heyer E, Zollikofer CPE, Ponce de León MS, Smith CI, Grimes V, Pike KA, Deal M, Fuller BT, Arriaza B, Standen V, Luz MF, Ricaut F, Guidon N, Osipova L, Voevoda MI, Posukh OL, Balanovsky O, Lavryashina M, Bogunov Y, Khusnutdinova E, Gubina M, Balanovska E, Fedorova S, Litvinov S, Malyarchuk B, Derenko M, Mosher MJ, Archer D, Cybulski J, Petzelt B, Mitchell J, Worl R, Norman PJ, Parham P, Kemp BM, Kivisild T, Tyler-Smith C, Sandhu MS, Crawford M, Villems R, Smith DG, Waters MR, Goebel T, Johnson JR, Malhi RS, Jakobsson M, Meltzer DJ, Manica A, Durbin R, Bustamante CD, Song YS, Nielsen R, Willerslev E. POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans. Science. 2015 Aug 21; 349(6250):aab3884.
PMID: 26198033

Ancient genomics.
Der Sarkissian C, Allentoft ME, Ávila-Arcos MC, Barnett R, Campos PF, Cappellini E, Ermini L, Fernández R, da Fonseca R, Ginolhac A, Hansen AJ, Jónsson H, Korneliussen T, Margaryan A, Martin MD, Moreno-Mayar JV, Raghavan M, Rasmussen M, Velasco MS, Schroeder H, Schubert M, Seguin-Orlando A, Wales N, Gilbert MT, Willerslev E, Orlando L. Ancient genomics. Philos Trans R Soc Lond B Biol Sci. 2015 Jan 19; 370(1660):20130387.
PMID: 25487338

Prehistoric genomes reveal the genetic foundation and cost of horse domestication.
Schubert M, Jónsson H, Chang D, Der Sarkissian C, Ermini L, Ginolhac A, Albrechtsen A, Dupanloup I, Foucal A, Petersen B, Fumagalli M, Raghavan M, Seguin-Orlando A, Korneliussen TS, Velazquez AM, Stenderup J, Hoover CA, Rubin CJ, Alfarhan AH, Alquraishi SA, Al-Rasheid KA, MacHugh DE, Kalbfleisch T, MacLeod JN, Rubin EM, Sicheritz-Ponten T, Andersson L, Hofreiter M, Marques-Bonet T, Gilbert MT, Nielsen R, Excoffier L, Willerslev E, Shapiro B, Orlando L. Prehistoric genomes reveal the genetic foundation and cost of horse domestication. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):E5661-9.
PMID: 25512547

Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.
Malaspinas AS, Lao O, Schroeder H, Rasmussen M, Raghavan M, Moltke I, Campos PF, Sagredo FS, Rasmussen S, Gonçalves VF, Albrechtsen A, Allentoft ME, Johnson PL, Li M, Reis S, Bernardo DV, DeGiorgio M, Duggan AT, Bastos M, Wang Y, Stenderup J, Moreno-Mayar JV, Brunak S, Sicheritz-Ponten T, Hodges E, Hannon GJ, Orlando L, Price TD, Jensen JD, Nielsen R, Heinemeier J, Olsen J, Rodrigues-Carvalho C, Lahr MM, Neves WA, Kayser M, Higham T, Stoneking M, Pena SD, Willerslev E. Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil. Curr Biol. 2014 Nov 03; 24(21):R1035-7.
PMID: 25455029

A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.
Clemente FJ, Cardona A, Inchley CE, Peter BM, Jacobs G, Pagani L, Lawson DJ, Antão T, Vicente M, Mitt M, DeGiorgio M, Faltyskova Z, Xue Y, Ayub Q, Szpak M, Mägi R, Eriksson A, Manica A, Raghavan M, Rasmussen M, Rasmussen S, Willerslev E, Vidal-Puig A, Tyler-Smith C, Villems R, Nielsen R, Metspalu M, Malyarchuk B, Derenko M, Kivisild T. A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations. Am J Hum Genet. 2014 11 06; 95(5):584-589.
PMID: 25449608

Ancient DNA reveals matrilineal continuity in present-day Poland over the last two millennia.
Juras A, Dabert M, Kushniarevich A, Malmström H, Raghavan M, Kosicki JZ, Metspalu E, Willerslev E, Piontek J. Ancient DNA reveals matrilineal continuity in present-day Poland over the last two millennia. PLoS One. 2014; 9(10):e110839.
PMID: 25337992

The genetic prehistory of the New World Arctic.
Raghavan M, DeGiorgio M, Albrechtsen A, Moltke I, Skoglund P, Korneliussen TS, Grønnow B, Appelt M, Gulløv HC, Friesen TM, Fitzhugh W, Malmström H, Rasmussen S, Olsen J, Melchior L, Fuller BT, Fahrni SM, Stafford T, Grimes V, Renouf MA, Cybulski J, Lynnerup N, Lahr MM, Britton K, Knecht R, Arneborg J, Metspalu M, Cornejo OE, Malaspinas AS, Wang Y, Rasmussen M, Raghavan V, Hansen TV, Khusnutdinova E, Pierre T, Dneprovsky K, Andreasen C, Lange H, Hayes MG, Coltrain J, Spitsyn VA, Götherström A, Orlando L, Kivisild T, Villems R, Crawford MH, Nielsen FC, Dissing J, Heinemeier J, Meldgaard M, Bustamante C, O'Rourke DH, Jakobsson M, Gilbert MT, Nielsen R, Willerslev E. The genetic prehistory of the New World Arctic. Science. 2014 Aug 29; 345(6200):1255832.
PMID: 25170159

Rodents of the Caribbean: origin and diversification of hutias unravelled by next-generation museomics.
Fabre PH, Vilstrup JT, Raghavan M, Sarkissian CD, Willerslev E, Douzery EJ, Orlando L. Rodents of the Caribbean: origin and diversification of hutias unravelled by next-generation museomics. Biol Lett. 2014 Jul; 10(7).
PMID: 25115033

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Neubauer Family Assistant Professors Program
University of Chicago
2018 - 2023