Anna Di Rienzo, PhD

Research in our labs focuses on the genetic architecture of traits and diseases that vary across human populations and on understanding the role of natural selection in shaping this architecture. To this end, we use empirical population genetics and functional genomics approaches coupled with computational analyses of genome-scale data.

University of California
San Francisco, CA
- Human Molecular Genetics
1992

University of California
Berkeley, CA
- Human Population Genetics
1991

Institute of Cell Biology, National Research Council
Rome, Italy
- Human Molecular Genetics
1988

University of Rome La Sapienza
Rome, Italy
- Medical Genetics
1984

University of Rome La Sapienza
Rome, Italy
- Human Genetics
1980

Inferring the model and onset of natural selection under varying population size from the site frequency spectrum and haplotype structure.
Nakagome S, Hudson RR, Di Rienzo A. Inferring the model and onset of natural selection under varying population size from the site frequency spectrum and haplotype structure. Proc Biol Sci. 2019 02 13; 286(1896):20182541.
PMID: 30963935

Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y. Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11349-E11358.
PMID: 30429326

The genetic prehistory of the Andean highlands 7000 years BP though European contact.
Lindo J, Haas R, Hofman C, Apata M, Moraga M, Verdugo RA, Watson JT, Viviano Llave C, Witonsky D, Beall C, Warinner C, Novembre J, Aldenderfer M, Di Rienzo A. The genetic prehistory of the Andean highlands 7000 years BP though European contact. Sci Adv. 2018 11; 4(11):eaau4921.
PMID: 30417096

Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal.
Jeong C, Witonsky DB, Basnyat B, Neupane M, Beall CM, Childs G, Craig SR, Novembre J, Di Rienzo A. Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal. PLoS Genet. 2018 09; 14(9):e1007650.
PMID: 30188897

The genomic landscape of Nepalese Tibeto-Burmans reveals new insights into the recent peopling of Southern Himalayas.
Gnecchi-Ruscone GA, Jeong C, De Fanti S, Sarno S, Trancucci M, Gentilini D, Di Blasio AM, Sherpa MG, Sherpa PT, Marinelli G, Di Marcello M, Natali L, Peluzzi D, Pettener D, Di Rienzo A, Luiselli D, Sazzini M. The genomic landscape of Nepalese Tibeto-Burmans reveals new insights into the recent peopling of Southern Himalayas. Sci Rep. 2017 Nov 14; 7(1):15512.
PMID: 29138459

Correction: A longitudinal cline characterizes the genetic structure of human populations in the Tibetan plateau.
Jeong C, Peter BM, Basnyat B, Neupane M, Beall CM, Childs G, Craig SR, Novembre J, Di Rienzo A. Correction: A longitudinal cline characterizes the genetic structure of human populations in the Tibetan plateau. PLoS One. 2017; 12(8):e0183407.
PMID: 28797074

A longitudinal cline characterizes the genetic structure of human populations in the Tibetan plateau.
Jeong C, Peter BM, Basnyat B, Neupane M, Beall CM, Childs G, Craig SR, Novembre J, Di Rienzo A. A longitudinal cline characterizes the genetic structure of human populations in the Tibetan plateau. PLoS One. 2017; 12(4):e0175885.
PMID: 28448508

Ethnically Tibetan women in Nepal with low hemoglobin concentration have better reproductive outcomes.
Cho JI, Basnyat B, Jeong C, Di Rienzo A, Childs G, Craig SR, Sun J, Beall CM. Ethnically Tibetan women in Nepal with low hemoglobin concentration have better reproductive outcomes. Evol Med Public Health. 2017; 2017(1):82-96.
PMID: 28567284

Colonic transcriptional response to 1a,25(OH)2 vitamin D3 in African- and European-Americans.
Alleyne D, Witonsky DB, Mapes B, Nakagome S, Sommars M, Hong E, Muckala KA, Di Rienzo A, Kupfer SS. Colonic transcriptional response to 1a,25(OH)2 vitamin D3 in African- and European-Americans. J Steroid Biochem Mol Biol. 2017 04; 168:49-59.
PMID: 28163244

Genetic structure in the Sherpa and neighboring Nepalese populations.
Cole AM, Cox S, Jeong C, Petousi N, Aryal DR, Droma Y, Hanaoka M, Ota M, Kobayashi N, Gasparini P, Montgomery H, Robbins P, Di Rienzo A, Cavalleri GL. Genetic structure in the Sherpa and neighboring Nepalese populations. BMC Genomics. 2017 01 19; 18(1):102.
PMID: 28103797

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