Carole Ober, Ph. D.

A genome screen with 295 markers and four diagnostic categories of asthma has been completed (Ober et al. 1998). All subjects were evaluated by the same criteria as that used in the Collaborative Study on the Genetics of Asthma (CSGA, 1997). The four diagnostic categories are: 1) past or current history of symptoms and BHR (i.e., "strict" asthma), 2) BHR with or without past or current history of symptoms, 3) past or current history of symptoms with or without BHR; and 4) past or current history of asthma or BHR (i.e., "loose" asthma). The transmission disequilibrium test (TDT) was used as one test of linkage.

Results of Genome Screen

Ober C, Cox N, Parry R, Abney M, DiRienzo A, Changyaleket B, Gidley H, et al (1998): Genome-wide search for asthma susceptibility loci in a founder population. Hum Molec Genet 7:1393-1398     Abstract

The Collaborative Study on the Genetics of Asthma (CSGA) (1997):  A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 15:389-92 Abstract

Complex Trait Mapping in the Hutterites

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