Genetic variation among extant individuals carries information about the evolutionary and genetic forces that have shaped their ancestors. Our research leverages this information to learn about recombination, demography and natural selection, in humans as well as in other species. To do so, we combine modeling, the development of statistical tools and data analysis.
Selected Publications
Coop, G., Wen, W., Ober, C., Pritchard, J. K., and M. Przeworski, 2008 High resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. Science 319: 1395-8.
Becquet, C., and M. Przeworski, 2007 A new method to estimate parameters of speciation models, with application to apes. Genome Research 17: 1505-19.
Teshima, K. M., Coop, G., and M. Przeworski. 2006 How reliable are empirical genomic scans for selective sweeps? Genome Research 16: 702-712.
Przeworski, M., Coop, G., and Wall, J. D. (2005). "The signature of positive selection on standing genetic variation." Evolution 59: 2312-2323.
Ptak, S. E., Roeder, A., Stephens, M., Gilad, Y., Paabo, S., and Przeworski, M. (2004). "Absence of the TAP2 human recombination hotspot in chimpanzees." PLoS Biology 2: 849-855.
Hellmann, I., Ebersberger, I., Ptak, S., Paabo, S. and Przeworski, M. (2003). "A neutral explanation for the correlation between diversity levels and recombination rates in humans." Am. J. Hum. Gen. 72: 1527-35.
Przeworski, M. (2002) "The signature of positive selection at randomly chosen loci." Genetics 160: 1179-1189.
Ptak, S., and Przeworski, M. (2002) "Evidence for population growth in humans is confounded by population structure." Trends in Gen. 18: 559-563.
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