Courses

 
REQUIRED COURSES 1st YEAR CURRICULUM:

HGEN 47000 Human Genetics I: Human Genetics. This course covers classical and modern approaches to studying cytogenetic, Mendelian, and complex human diseases. Topics include chromosome biology, single gene and complex diseases, non-Mendelian inheritance, cancer genetics, human population genetics, and genomics. The format includes lectures and student presentations. Autumn.

MGCB 31400 Genetic Analysis of Model Organisms. Coverage of the fundamental tools of genetic analysis as used to study biological phenomena. Topics include genetic exchange in prokaryotes and eukaryotes, analysis of gene function, and epigenetics. Autumn.

HGEN 46900 Human Genetics II: Human Variation and Disease. This course focuses on principles of population and evolutionary genetics and complex trait mapping as they apply to humans. It will include the discussion of genetic variation and disease mapping data. Spring.

HGEN 31900 Introduction to Research. Lectures on current research by departmental faculty and other invited speakers. A required course for all first-year graduate students in Human Genetics. Autumn, Winter.

HGEN 40300 Non-Thesis Research . Laboratory rotations, and all research prior to passing the Qualifying Examination. Autumn, Winter, Spring, Summer.

BSDG 55000 Scientific Ethics Seminar . Required of all First Year BSD grad students. Spring

CHOOSE ONE OF THE FOLLOWING TO FULFILL 1 COURSE REQUIREMENT:

HGEN 47100 Human Genetics III: Introductory Statistical Genetics. This course focuses on genetic models for complex human disorders and quantitative traits. Topics covered also include linkage and linkage disequilibrium mapping genetic models for complex traits, and the explicit and implicit assumptions of such models. Winter.

MGCB 31500 Genetic Mechanisms. Advanced coverage of genetic mechanisms involved in genome stability and rearrangement in lower and higher organisms. Topics include the genetics of mutagenesis, DNA repair, homologous and site specific recombination, transposition and chromosome segregation. Winter.

ECEV 35600 Population Genetics I. Examines the basic theoretical principles of population genetics, and their application to the study of variation and evolution in natural populations. Topics include selection, mutation, random genetic drift, quantitative genetics, molecular evolution and variation, the evolution of selfish genetic systems, and human evolution. Winter.

MGCB 31200 Molecular Biology I. Nucleic acid structure and DNA topology; methodology; nucleic-acid protein interactions; mechanisms and regulation of transcription in eubacteria, and of replication in eubacteria and eukaryotes; mechanisms of genome and plasmid segregation in eubacteria. Winter

MGCB 31300 Molecular Biology II. Eukaryotic Gene Expression. Transcription and Posttranscriptional Regulation. Analysis of regulatory pathways and mechanisms involved in the control of eukaryotic gene activity. Spring.

ADDITIONAL ELECTIVE COURSES TO CHOOSE FROM TO FULFILL 4 COURSES:
HUMAN GENETICS

HGEN 39900 Readings in Human Genetics. A course designed by students and faculty member. All reading courses must be approved by the Curriculum/Student Affairs Committee prior to registration. Autumn, Winter, Spring, Summer

HGEN 47300 Genomics and Systems Biology. This lecture course explores technologies for high-throughput collection of genomic-scale data, including sequencing, genotyping, gene expression profiling, and assays of copy number variation, protein expression and protein-protein interaction. In addition, the course will cover study design and statistic analysis of large data sets, as well as how data from different sources can be used to understand regulatory networks, i.e., systems. Statistical tools that will be introduced include linear models, likelihood-based inference, supervised and unsupervised learning techniques, methods for assessing quality of data, hidden Markov models, and controlling for false discovery rates in large data sets. Readings will be drawn from the primary literature. Evaluation will be based primarily on problem sets. Spring.

HGEN 47400 Introduction to Probability and Statistics for Geneticists. This course is an introduction to basic probability theory and statistical methods useful for people who intend to do research in genetics or a similar scientific field. Topics include random variable and probability distributions, descriptive statistics, hypothesis testing and parameter estimation. Problem sets and tests will include both solving problems analytically and analysis of data using the R statistical computing environment.

BIOCHEMISTRY AND MOLECULAR BIOLOGY

BCMB 30400 Protein Fundamentals. The course covers the physico‑chemical phenomena that define protein structure and function. Topics include: 1) the interactions/forces that define polypeptide conformation; 2) the principles of protein folding, structure and design; and 3) the concepts of molecular motion, molecular recognition, and enzyme catalysis. PQ: BMB 30100, which may be taken concurrently, or equivalent. Autumn.

DEVELOPMENTAL BIOLOGY

DVBI 35400 Advanced Developmental Biology. This course provides an overview of the fundamental questions of developmental biology, presenting both the classical embryological experiments that defined these questions, and the modern molecular and genetic experiments that have been employed to try to reach mechanistic answers to these questions. The first portion of the course will focus on the mechanism of axis formation in a variety of organisms; the second part of the course will explore selected topics in the field. Fall.

DVBI 35500 Developmental Genetics of Non-vertebrate Model Systems. This course explores the use of genetics in three different model systems, C. elegans, Drosophila melanogaster and Arabodopsis thaliana, to elucidate developmental mechanisms. The class will focus on a series of interrelated topics: for each topic, introductory material presented by the lecturer will be followed by student-led discussions of individual papers. Winter.

ECOLOGY AND EVOLUTION

ECEV 35700 Population Genetics II. Examines the basic theoretical principles of population genetics, and their application to the study of variation and evolution in natural populations. Topics include selection, mutation, random genetic drift, quantitative genetics, molecular evolution and variation, the evolution of selfish genetic systems, and human evolution. Spring.

ECEV 35800 Classics of Evolutionary Genetics. Major classic papers in evolutionary genetics that had great impact on the development of the field are reviewed.

ECEV 35900 Genomic Evolution. We focus on the newly proposed and solved problems related to evolution of genomes. Instructors will give a series of lectures, dealing with basic concepts and techniques used in the research of topics. Students will present and evaluate literatures.

ECEV 36300 Speciation. A review of the literature on the origin of species beginning with Darwin and continuing through contemporary work. Both theoretical and empirical studies will be covered, with special emphasis on the genetics of speciation.

ECEV 37500 Sexual Selection. A discussion and critical analysis of sexual selection. The course will consist of lectures, reading and discussion. Spring

MOLECULAR GENETICS AND CELL BIOLOGY

MGCB 31600 Cell Biology I. Eukaryotic protein traffic and related topics, including molecular motors and cytoskeletal dynamics, organelle architecture and biogenesis, protein translocationand sorting, compartmentalization in the secretory pathway, endocytosis and exocytosis, and mechanisms and regulation of membrane fusion. Autumn.

MGCB 31700 Cell Biology II. Chromatin structure and its role in transcription communication between nucleus and cytoplasm, translation, protein folding and assembly, molecular chaperones, elements of signal transduction, homeostasis, growth control and the cell cycle, cytoarchitecture, cell adhesion and migration. Winter.

MGCB 36100 Plant Development and Molecular Genetics. Growth, differentiation and development in plants at the organismal, cellular, and molecular level. The regulatory function of environmental factors, hormones and phytochrome on gene expression and the possible evolutionary relationships will be studied. The molecular genetic advances in Arabidopsis and maize are a central feature of the course. Spring

MICROBIOLOGY

MICR 34000 Bacterial Pathogenesis. This course focuses on the genetics and molecular biology of bacterial pathogens with emphasis on host-pathogen interactions. The course will cover topics ranging from toxin production and secretion to evasion of host-responses and antibiotic resistance. Current techniques and discoveries will be covered in a paper-based discussion section. Winter.

STATISTICS

STAT 22000 Statistic Methods and Applications. Statistics 22000 provides an introduction to how statisticians think about describing data, data collection and research design, probability and randomness, and inference from a sample to a population. This course would only be appropriate for students with too little background to take HGEN 47400 or STAT 24400. Fall, Winter, and Spring.

STAT 24400-24500 Statistical Theory and Methodology I, II. Principles and techniques of statistics with emphasis on the analysis of experimental data. First quarter: Discrete and continuous probability distributions, transformation of random variables; principles of inference including Bayesian inference, maximum likelihood estimation, hypothesis testing, likelihood-ratio tests, multinomial distributions and chi-square tests. Second quarter: Multivariate normal distributions and transformations, Poison processes, data analysis, t-tests, confidence intervals, analysis of variance and regression analysis. Autumn, Winter.

STAT 35500 Statistical Genetics. This is an advanced course in statistical genetics. Prerequisites are Human Genetics 47100 and Statistics 24400 and 24500. Students who do not meet the prerequisites may enroll on a P/NP basis with consent of the instructor. Prerequisites are either Human Genetics 47100 or statistics preparation at the level of Statistics 24400 and 24500. This is a discussion course and student presentations will be required. Topics vary and may include, but are not limited to, statistical problems in linkage mapping, association mapping, map construction, and genetic models for complex traits. Spring

TRANSLATIONAL MEDICINE

CCTS 40001 Pharmacogenomics. As pharmacogenomic advances allow for individualized drug therapies based on genotypic information, the cost of and morbidity from drug toxicity is expected to decrease, and drug efficacy is expected to increase. The ethics and economics of pharmacogenomics will also be discussed. Spring