GTEx findings reveal new insights into how DNA differences influence gene activity, disease susceptibility
HGEN 47000 Human Genetics I. Ober, Nobrega, Waggoner. This course covers classical and modern approaches to studying cytogenetic, Mendelian, and complex human diseases. Topics include chromosome biology, single gene and complex diseases, non-Mendelian inheritance, cancer genetics, human population genetics, and genomics. The format includes lectures and student presentations. Autumn.
MGCB 31400 Genetic Analysis of Model Organisms. Palmer. Coverage of the fundamental tools of genetic analysis as used to study biological phenomena. Topics include genetic exchange in prokaryotes and eukaryotes, analysis of gene function, and epigenetics. Autumn.
HGEN 46900 Human Variation and Disease. Di Rienzo, Novembre. This course focuses on principles of population and evolutionary genetics and complex trait mapping as they apply to humans. It will include the discussion of genetic variation and disease mapping data. Spring.
HGEN 31900 Introduction to Research. Lectures on current research by departmental faculty and other invited speakers. A required course for all first-year graduate students in Human Genetics. Autumn, Winter.
HGEN 40300 Non-Thesis Research. Laboratory rotations, and all research prior to passing the Qualifying Examination. Autumn, Winter, Spring, Summer.
BSDG 55000 Scientific Ethics Seminar. Required of all First Year BSD grad students. Spring
HGEN 47100 Human Genetics III: Introductory Statistical Genetics. Cox, Novembre. This course focuses on genetic models for complex human disorders and quantitative traits. Topics covered also include linkage and linkage disequilibrium mapping genetic models for complex traits, and the explicit and implicit assumptions of such models. Winter.
HGEN 31100 Evolution of Biological Molecules. Thornton,Drummond. Introductory graduate-level course connects evolutionary changes imprinted in genes and genomes with the structure, function and behavior of the encoded protein and RNA molecules. Central themes are the mechanisms and dynamics by which molecular structure and function evolve, how protein/RNA architecture shapes evolutionary trajectories, and how patterns in present-day sequence can be interpreted to reveal the interplay data of evolutionary history and molecular properties. Winter
GENE 32500 Evolutionary Aspects of Gene Regulation. Ruvinsky. This is a “Reading & Participation” class. Students will read, present and discuss primary research papers. These will cover basics of molecular mechanisms of gene regulation, as well as a variety of comparative studies exploring how gene regulation has changed during evolution. The core goal of the class is to learn how to critically analyze papers and design experiments.Winter
ECEV 35600 Population Genetics I. Hudson. Examines the basic theoretical principles of population genetics, and their application to the study of variation and evolution in natural populations. Topics include selection, mutation, random genetic drift, quantitative genetics, molecular evolution and variation, the evolution of selfish genetic systems, and human evolution. Winter.
HGEN 47300 Genomics and Systems Biology. Gilad. This lecture course explores technologies for high-throughput collection of genomic-scale data, including sequencing, genotyping, gene expression profiling, and assays of copy number variation, protein expression and protein-protein interaction. In addition, the course will cover study design and statistic analysis of large data sets, as well as how data from different sources can be used to understand regulatory networks, i.e., systems. Statistical tools that will be introduced include linear models, likelihood-based inference, supervised and unsupervised learning techniques, methods for assessing quality of data, hidden Markov models, and controlling for false discovery rates in large data sets. Readings will be drawn from the primary literature. Evaluation will be based primarily on problem sets. Spring.
MGCB 31300 Molecular Biology II. Ruthenberg/Staley. Eukaryotic Gene Expression. Transcription and Posttranscriptional Regulation. Analysis of regulatory pathways and mechanisms involved in the control of eukaryotic gene activity. Spring.
DVBI 35600 Vertebrate Developmental Genetics. Prince. This advanced-level course combines lectures, student presentations, and discussion sections. It covers major topics in the developmental biology of vertebrate embryos (e.g., formation of the germ line, gastrulation, segmentation, nervous system development, limb patterning, organogenesis). The course makes extensive use of the current primary literature and emphasizes experimental approaches including embryology, genetics, and molecular genetics. Spring.