Xiaochang Zhang, Ph.D.

Assistant Professor

Office Address: CLSC 507A
Telephone number: 773 834 5369

Research Description:

How our brain is developed and evolved remains a major question in biology, and abnormal development of the human brain can cause autism and epilepsy. We study fundamental mechanisms of brain development and disorders, and our specific interests include: tracing cell lineages in mammalian brains, genetic mechanisms of neuronal type specification, and roles of alternative RNA splicing in neural development and diseases. We develop and apply single cell approaches, animal models, and functional genomics to address these questions.

Lab Webpage:

http://zhanglaboratory.org/

Selected Publications:

Zhang, X., Chen, M.H., Wu, X., Kodani, A., Fan, J., Doan, R., Ozawa, M., Ma, J., Yoshida, N., Reiter, J.F., Black, D.L. Kharchenko, P.V. Sharp, P.A. Walsh, C.A. (2016). Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell 166, 1147-1162 e1115. (Corresponding authors, cover story)

Jamuar, S.S., Lam, A.T., Kircher, M., D'Gama, A.M., Wang, J., Barry, B.J., Zhang, X., Hill, R.S., Partlow, J.N., Rozzo, A., Servattalab, S., Mehta, B.K., Topcu, M., Amrom, D., Andermann, E., Dan, B., Parrini, E., Guerrini, R., Scheffer, I.E., Berkovic, S.F., Leventer, R.J., Shen, Y., Wu, B.L., Barkovich, A.J., Sahin, M., Chang, B.S., Bamshad, M., Nickerson, D.A., Shendure, J., Poduri, A., Yu, T.W., and Walsh, C.A.. (2014). Somatic mutations in cerebral cortical malformations. The New England Journal of Medicine 371, 733-743.

Zhang, X.*, Ling, J.*, Barcia, G.*, Jing, L., Wu, J., Barry, B.J., Mochida, G.H., Hill, R.S., Weimer, J.M., Stein, Q., Poduri, A., Partlow, J.N., Ville, D., Dulac, O., Yu, T.W., Lam, A.T., Servattalab, S., Rodriguez, J., Boddaert, N., Munnich, A., Colleaux, L., Zon, L.I., Soll, D., Walsh, C.A., and Nabbout, R. (2014). Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures. Am J Hum Genet 94, 547-558. (*Co-first authors, corresponding authors)

Zhang, X., Zabinsky, R., Teng, Y., Cui, M., and Han, M. (2011). microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause. Proc Natl Acad Sci USA 108, 17997-18002.

Zhang, X., and Han, M. (2010). Nuclear migration: rock and roll facilitated by dynein and kinesin. Curr Biol 20, R1027-1029. (Invited review)

Zhang, X., Lei, K., Yuan, X., Wu, X., Zhuang, Y., Xu, T., Xu, R., and Han, M. (2009). SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron 64, 173-187. (Accompanied by a Mini-review, highlighted by Nature China and Faculty of 1000)

Lei, K.*, Zhang, X.*, Ding, X., Guo, X., Chen, M., Zhu, B., Xu, T., Zhuang, Y., Xu, R., and Han, M. (2009). SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci USA 106, 10207-10212. (*Co-first authors)

Zhang, X., Xu, R., Zhu, B., Yang, X., Ding, X., Duan, S., Xu, T., Zhuang, Y., and Han, M. (2007). Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development 134, 901-908. (Highlighted by Faculty of 1000)