Elliot Gershon, M.D.


Research Description

Our overarching goal is to identify genes and genomic mechanisms in neuropsychiatric disorders.  With my close collaborator Prof. Chunyu Liu at UIC, we have published studies on functional genomics of brain. These include pioneering genome-wide studies that revealed common genetic variants (quantitative trait loci; QTLs) that control of gene expression and methylation.  With Prof. Nancy Cox and her postdoc Dr. Eric Gamazon, we have incorporated these findings into genetic association analyses of Bipolar and other disorders.  We have also developed gene networks with differential expression in neuropsychiatric disorders.

Copy Number Variants (CNVs) are chromosomal microdeletions and microduplications that can be discovered through genome-wide analyses.  These CNVs are too small to be discovered by microscopic methods, although they can be tagged once they are discovered.  Rare CNVs play a major role in several psychiatric disorders, and this is another major research interest of our group.  We have contributed to discovery of rare CNV burden in psychiatric disorders, and to the role of de novo CNVs in these disorders.  We are also studying rare single nucleotide polymorphisms (SNPs) in Bipolar disorder.

Our other major interests are in somatic mutation in brain in neuropsychiatric disorders, genetic counseling in neuropsychiatric disorders, and  pharmacogenomics of medication response in Bipolar Disorder.

Selected Publications

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
Hou L et al.
(2016 Aug) Hum Mol Genet. 2016 Aug 1;25(15):3383-3394. doi: 10.1093/hmg/ddw181. Epub 2016 Jun 21. 27329760 (Full Text)

Impaired Context Processing is Attributable to Global Neuropsychological Impairment in Schizophrenia and Psychotic Bipolar Disorder.
Reilly JL, Hill SK, Gold JM, Keefe RS, Clementz BA, Gershon E, Keshavan MS, Pearlson G, Tamminga CA, Sweeney JA
(2016 Jun) Schizophr Bull. 2016 Jun 15. pii: sbw081. 27306316

Polygenic risk for type 2 diabetes mellitus among individuals with psychosis and their relatives.
Padmanabhan JL, Nanda P, Tandon N, Mothi SS, Bolo N, McCarroll S, Clementz BA, Gershon ES, Pearlson GD, Sweeney JA, Tamminga CA, Keshavan MS
(2016 Jun) J Psychiatr Res. 2016 Jun;77:52-8. doi: 10.1016/j.jpsychires.2016.02.015. Epub 2016 Feb 23. 26978185 (Full Text)

The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample.
Oedegaard KJ et al.
(2016 May) BMC Psychiatry. 2016 May 5;16:129. doi: 10.1186/s12888-016-0732-x. 27150464 (Full Text)

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Franke B et al.
(2016 Mar) Nat Neurosci. 2016 Mar;19(3):420-31. doi: 10.1038/nn.4228. Epub 2016 Feb 1. 26854805 (Full Text)

Sex and diagnosis specific associations between DNA methylation of the oxytocin receptor gene with emotion processing and temporal-limbic and prefrontal brain volumes in psychotic disorders.
Rubin LH, Connelly JJ, Reilly JL, Carter CS, Drogos LL, Pournajafi-Nazarloo H, Ruocco AC, Keedy SK, Matthew I, Tandon N, Pearlson GD, Clementz BA, Tamminga CA, Gershon ES, Keshavan MS, Bishop JR, Sweeney JA
(2016 Mar) Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Mar 1;1(2):141-151. Epub 2015 Nov 9. 26977453 (Full Text)

Schizophrenia risk from complex variation of complement component 4.
Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE, Daly MJ, Carroll MC, Stevens B, McCarroll SA
(2016 Feb) Nature. 2016 Feb 11;530(7589):177-83. doi: 10.1038/nature16549. Epub 2016 Jan 27. 26814963 (Full Text)

Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study.
Lencer R, Sprenger A, Reilly JL, McDowell JE, Rubin LH, Badner JA, Keshavan MS, Pearlson GD, Tamminga CA, Gershon ES, Clementz BA, Sweeney JA
(2015 Dec) Schizophr Res. 2015 Dec;169(1-3):326-33. doi: 10.1016/j.schres.2015.09.032. Epub 2015 Oct 23. 26481615 (Full Text)

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis.
Loh PR, Bhatia G, Gusev A, Finucane HK, Bulik-Sullivan BK, Pollack SJ, de Candia TR, Lee SH, Wray NR, Kendler KS, O'Donovan MC, Neale BM, Patterson N, Price AL
(2015 Dec) Nat Genet. 2015 Dec;47(12):1385-92. doi: 10.1038/ng.3431. Epub 2015 Nov 2. 26523775 (Full Text)

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder.
Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Odegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J
(2015 Nov) Nature. 2015 Nov 5;527(7576):95-9. doi: 10.1038/nature15526. Epub 2015 Oct 28. 26524527 (Full Text)

Elevated antisaccade error rate as an intermediate phenotype for psychosis across diagnostic categories.
Reilly JL, Frankovich K, Hill S, Gershon ES, Keefe RS, Keshavan MS, Pearlson GD, Tamminga CA, Sweeney JA
(2014 Sep) Schizophr Bull. 2014 Sep;40(5):1011-21. doi: 10.1093/schbul/sbt132. Epub 2013 Sep 30. 24080895 (Full Text)

A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain.
Gershon ES, Grennan K, Busnello J, Badner JA, Ovsiew F, Memon S, Alliey-Rodriguez N, Cooper J, Romanos B, Liu C
(2014 Aug) Mol Psychiatry. 2014 Aug;19(8):890-4. doi: 10.1038/mp.2013.107. Epub 2013 Aug 27. 23979604 (Full Text)

Expression of the G72/G30 gene in transgenic mice induces behavioral changes.
Cheng L, Hattori E, Nakajima A, Woehrle NS, Opal MD, Zhang C, Grennan K, Dulawa SC, Tang YP, Gershon ES, Liu C
(2014 Feb) Mol Psychiatry. 2014 Feb;19(2):175-83. doi: 10.1038/mp.2012.185. Epub 2013 Jan 22. 23337943 (Full Text)

Boosting the power of schizophrenia genetics by leveraging new statistical tools.
Andreassen OA, Thompson WK, Dale AM
(2014 Jan) Schizophr Bull. 2014 Jan;40(1):13-7. doi: 10.1093/schbul/sbt168. Epub 2013 Dec 6. 24319118 (Full Text)

Two gene co-expression modules differentiate psychotics and controls.
Chen C, Cheng L, Grennan K, Pibiri F, Zhang C, Badner JA, Gershon ES, Liu C
(2013 Dec) Mol Psychiatry. 2013 Dec;18(12):1308-14. doi: 10.1038/mp.2012.146. Epub 2012 Nov 13. 23147385 (Full Text)

Neuropsychological impairments in schizophrenia and psychotic bipolar disorder: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study.
Hill SK, Reilly JL, Keefe RS, Gold JM, Bishop JR, Gershon ES, Tamminga CA, Pearlson GD, Keshavan MS, Sweeney JA
(2013 Nov) Am J Psychiatry. 2013 Nov;170(11):1275-84. doi: 10.1176/appi.ajp.2013.12101298. 23771174 (Full Text)

Neurophysiological evidence of corollary discharge function during vocalization in psychotic patients and their nonpsychotic first-degree relatives.
Ford JM, Mathalon DH, Roach BJ, Keedy SK, Reilly JL, Gershon ES, Sweeney JA
(2013 Nov) Schizophr Bull. 2013 Nov;39(6):1272-80. doi: 10.1093/schbul/sbs129. Epub 2012 Nov 15. 23155183 (Full Text)

New ethical issues for genetic counseling in common mental disorders.
Gershon ES, Alliey-Rodriguez N
(2013 Sep) Am J Psychiatry. 2013 Sep;170(9):968-76. doi: 10.1176/appi.ajp.2013.12121558. 23897273

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Lee SH et al.
(2013 Sep) Nat Genet. 2013 Sep;45(9):984-94. doi: 10.1038/ng.2711. Epub 2013 Aug 11. 23933821 (Full Text)

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

(2013 Apr) Lancet. 2013 Apr 20;381(9875):1371-9. doi: 10.1016/S0140-6736(12)62129-1. Epub 2013 Feb 28. 23453885 (Full Text)

Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder.
Greenwood TA, Kelsoe JR
(2013) PLoS One. 2013;8(1):e53804. doi: 10.1371/journal.pone.0053804. Epub 2013 Jan 10. 23326512 (Full Text)

Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants.
Gamazon ER et al.
(2013 Mar) Mol Psychiatry. 2013 Mar;18(3):340-6. doi: 10.1038/mp.2011.174. Epub 2012 Jan 3. 22212596 (Full Text)

Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nothen MM, Rietschel M, McMahon FJ, Farmer A, McGuffin P, Craig I, Lewis C, Hosang G, Cohen-Woods S, Vincent JB, Kennedy JL, Strauss J
(2013 Feb) Mol Psychiatry. 2013 Feb;18(2):195-205. doi: 10.1038/mp.2011.157. Epub 2011 Dec 20. 22182935