Professor, Department of Human Genetics and Department of Ecology & Evolution
Director, Institute for Genomics and Systems Biology at the University of Chicago and Argonne National Laboratory
Pritzker fellow, The University of Chicago and the Pritzker School of Medicine
Ph.D. Stanford University, 1998
Fax: (773) 834-2877
Mapping the regulatory wiring diagrams encoded in genomes is key to understanding development, disease and evolution. The White lab studies the coordinated action of networks of genes that control developmental and evolutionary processes. We have particular focus on building genome-wide models of transcriptional networks, and we use an integrated approach that makes use of gene expression microarrays, large-scale protein-protein and protein-DNA interaction analyses, systematic RNAi analysis and high throughput polymorphism detection. By applying our methods to both closely and distantly related species, we are investigating how conserved molecular networks control basic developmental processes and how variation in molecular networks translates into variation in organismal phenotypes. We are particularly interested in the transcriptional networks controlled by nuclear receptor proteins in development and disease. We also are studying the transcriptional mechanisms involved in patterning early embryos. We make use of the compact Drosophila genome and the genomes of related species as model systems for many of our studies, and recently we have also begun to apply these genomics and computational approaches to investigations of the human genome.
CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia.
A comprehensive nuclear receptor network for breast cancer cells.
(Feb 2013) Cell reports 3(2):538-51 PMID:23375374
Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome.
A cis-regulatory map of the Drosophila genome.
Identification of functional elements and regulatory circuits by Drosophila modENCODE.
Genomic antagonism between retinoic acid and estrogen signaling in breast cancer.
Unlocking the secrets of the genome.
Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer.
Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression.
Expression profiling in primates reveals a rapid evolution of human transcription factors.
(Mar 2006) Nature 440(7081):242-5 PMID:16525476
A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression.
(Nov 2005) Nature 438(7065):220-3 PMID:16281035
A gene expression map for the euchromatic genome of Drosophila melanogaster.
(Oct 2004) Science (New York, N.Y.) 306(5696):655-60 PMID:15499012
A protein interaction map of Drosophila melanogaster.
(Dec 2003) Science (New York, N.Y.) 302(5651):1727-36 PMID:14605208
Evolution of gene expression in the Drosophila melanogaster subgroup.
(Feb 2003) Nature genetics 33(2):138-44 PMID:12548287
Gene expression during the life cycle of Drosophila melanogaster.
(Sep 2002) Science (New York, N.Y.) 297(5590):2270-5 PMID:12351791