Department of Medicine/Section of Hematology/Oncology
Department of Human Genetics
Committee on Cancer Biology
Committee on Genetics
The Cancer Research Center
Fax: (773) 702-9311
Human tumors are characterized by recurring chromosomal abnormalities. During the past few years, the genes that are located at the breakpoints of a number of recurring chromosomal abnormalities in human tumors have been identified. Molecular analysis has revealed that alterations in the level of expression of these genes, or in the properties of the encoded proteins resulting from the chromosomal rearrangement, play an integral role in the process of malignant transformation. My research interests are:
- to identify the recurring chromosomal abnormalities in human tumors;
- to correlate specific chromosomal abnormalities with morphological and clinical features of the neoplastic disease, such as response to therapy and survival;
- to identify the genes located at the breakpoints of the recurring abnormalities using the techniques of molecular genetics, and to examine their function in malignant cells characterized by these chromosomal abnormalities;
- to localize genes to human chromosomes by using the technique of in situ chromosomal hybridization and to examine the location of specific genes relative to the breakpoints of recurring abnormalities in hematopoietic neoplastic diseases; and
- to examine the relationship of chromosomal fragile sites (loci which are prone to undergo breakage and rearrangement) and cancer-specific breakpoints.
Activation of Wnt/β-catenin protein signaling induces mitochondria-mediated apoptosis in hematopoietic progenitor cells.
Impaired replication dynamics at the FRA3B common fragile site.
Cancer: hay in a haystack.
(Jan 2008) Nature 451(7176):252-3 PMID:18202630
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.
High-throughput mapping of origins of replication in human cells.
Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series.
(Jul 2003) Blood 102(1):43-52 PMID:12623843
A critical role for Apc in hematopoietic stem and progenitor cell survival.
Haploinsufficiency of Apc leads to ineffective hematopoiesis.
Common fragile sites are characterized by histone hypoacetylation.
New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge.
(Mar 2012) Journal of clinical oncology : official journal of the American Society of Clinical Oncology 30(8):820-9 PMID:22331955