My research concerns primarily the analysis and interpretation of molecular variation within and between populations. The goal is to understand the evolutionary forces that have produced the observed patterns of variation within populations and between species. My work is entirely theoretical, focusing on the stochastic processes relevant to evolution in finite populations in which genetic drift, mutation, migration and selection may all be important. Monte Carlo computer simulations and methods of statistical inference are important aspects of the work. Much of my past work has focused on Drosophila data, in the future it is likely that human variation will be a major focus.
Kaplan, N.L., Hudson, R. R. and Iizuka, M. (1991) The coalescent process in models with selection, recombination and geographic subdivision. Genetical Research 57:83-91.
Slatkin, M. and Hudson, R. R. (1991) Pairwise comparisons of mitochondrial DNA sequences ins stable and exponentially growing populations. Genetics
Hudson, R. R., Bailey, K., Skarecky, D., Kwiatowski, J., and Ayala, F. J. (1994) Evidence for positive selection in the superoxide dismutase (Sod) region of Drosophila melanogaster. Genetics 136:1329-1340.
Hudson, R. R. and Kaplan, N.L. (1995) Deletorious background selection with recombination. Genetics 141:1605-1617.
Hudson, R.R. (1998) Island models and the coalescent process. J. Molecular Ecology: 7:413-418.
Rich, S.M., Licht, M.C., Hudson, R.R., and Ayala, F.J. (1998) Malaria’s Eve: Evidence of a recent population bottleneck throughout the world populations of Plasmodium falciparum. Proc. Natl. Acal. Sci. (USA) 95:4425-4430.