Phone: (773) 834-1984 (lab)
Fax: (773) 834-8470
One of the main challenges for geneticists in the 'post-genome' era is to understand the genetic architecture of gene regulation and how differences in gene regulation affect complex phenotypes, including human diseases. While many groups are studying gene regulatory mechanisms in model organisms, we reasoned that, although more challenging, the study of gene regulation in primates may carry rewards that are immediately applicable to humans. By collecting valuable samples, developing and adapting new technologies, and combining expertise in evolutionary biology, comparative genetics, and genomics, our lab has made key contributions to the study of gene regulation in humans.
Comparative studies of gene expression and the evolution of gene regulation.
(Jul 2012) Nature reviews. Genetics 13(7):505-16 PMID:22705669
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Social environment is associated with gene regulatory variation in the rhesus macaque immune system.
DNase I sensitivity QTLs are a major determinant of human expression variation.
(Feb 2012) Nature 482(7385):390-4 PMID:22307276
Dissecting the regulatory architecture of gene expression QTLs.
Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data.
Genomic-scale capture and sequencing of endogenous DNA from feces.
Functional comparison of innate immune signaling pathways in primates.
Noisy splicing drives mRNA isoform diversity in human cells.
Natural selection on gene expression
(2006)Trends in Genetics. 8: 456-461
The evolution of the human olfactory receptor gene repertoire
(2006)New Encyclopedia of Neuroscience
Using DNA microarrays to study natural variation.
(Dec 2006) Current opinion in genetics & development 16(6):553-8 PMID:17008090
Expression profiling in primates reveals a rapid evolution of human transcription factors.
(Mar 2006) Nature 440(7081):242-5 PMID:16525476
Initial sequence of the chimpanzee genome and comparison with the human genome.
(Sep 2005) Nature 437(7055):69-87 PMID:16136131
Multi-species microarrays reveal the effect of sequence divergence on gene expression profiles.
A comparison of the human and chimpanzee olfactory receptor gene repertoires.
Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons.
Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates.
Natural selection on the olfactory receptor gene family in humans and chimpanzees.
Different noses for different people.
(Jun 2003) Nature genetics 34(2):143-4 PMID:12730696
Human specific loss of olfactory receptor genes.