Ph.D. (Physics), University of Chicago, 1996
Fax: (773) 834-0505
My research focuses on problems in statistical and computational genetics. In general, my interests are in developing both new mathematical methods and computational techniques to overcome complex problems in the analysis of genetic data. I believe that by providing improved methods to researchers that make more efficient use of data as well as integrate a wider range of information, I will have a positive impact on the scientific insights and conclusions that are drawn. I have recently been concentrating my research in the area of complex trait mapping, with application to the analysis of quantitative traits in the Hutterites. The size and complexity of the Hutterite pedigree (13 generations, 1,623 individuals) make most standard analyses intractable, unless drastic simplifications of the genealogy are undertaken. Instead, Drs. Mary Sara McPeek, Carole Ober and I have developed methods for linkage and linkage disequilibrium mapping within the variance component framework that makes full use of the pedigree information (Abney et al 2000, 2002). Further work with Dr. McPeek includes implementation of a novel permutation-based test of significance.
Using identity by descent estimation with dense genotype data to detect positive selection.
Estimating the human mutation rate using autozygosity in a founder population.
GLOGS: a fast and powerful method for GWAS of binary traits with risk covariates in related populations.
Fine-mapping alleles for body weight in LG/J × SM/J F₂ and F(34) advanced intercross lines.
Identity by descent estimation with dense genome-wide genotype data.
Genetic variance components estimation for binary traits using multiple related individuals.
(Jul 2011) Genetic epidemiology 35(5):291-302 PMID:21465547
The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate.
Colloquium papers: Heritability of reproductive fitness traits in a human population.
A graphical algorithm for fast computation of identity coefficients and generalized kinship coefficients.
Identity-by-descent estimation and mapping of qualitative traits in large, complex pedigrees.
Heritability estimation of sex-specific effects on human quantitative traits.
(May 2007) Genetic epidemiology 31(4):338-47 PMID:17323368
The sex-specific genetic architecture of quantitative traits in humans.
(Feb 2006) Nature genetics 38(2):218-22 PMID:16429159
Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites.
The genetic dissection of complex traits in a founder population.
Broad and narrow heritabilities of quantitative traits in a founder population.
Detection of mis-specified relationships in inbred and outbred pedigrees.
(2001) Genetic epidemiology 21 Suppl 1:S36-41 PMID:11793699
Estimation of variance components of quantitative traits in inbred populations.